Loading…
useR! 2024
Attending this event?
In Person
8 - 11 July, 2024
Learn more and Register to Attend

The Sched app allows you to build your schedule but is not a substitute for your event registration. You must be registered for useR! 2024 to participate in the sessions. If you have not registered but would like to join us, please go to the event registration page to purchase a registration.

Please note: This schedule is automatically displayed in Central European Summer Time (UTC+02:00). To see the schedule in your preferred timezone, please select from the drop-down menu to the right, above "Filter by Date." The schedule is subject to change.

IMPORTANT NOTE: Timing of sessions and room locations are subject to change.

The virtual program will take place on 2 July. Please see the virtual schedule page for more information.
Back To Schedule
Tuesday, July 9 • 12:00 - 12:20
MS Meets R: Unravelling Cellular Lipid Networks by Integrative Analysis & Untangling Ether Lipids Th - Jakob Koch, Medical University of Innsbruck

Sign up or log in to save this to your schedule, view media, leave feedback and see who's attending!

Tweet Share
Membrane balance relies on specific metabolic lipid interactions. We investigated how fatty acyl side chains from different lipid classes influence each other using artificial neural networks (ANNs). We analyzed profiles of different phospholipids from 15 mouse tissues and found tissue-specific patterns. With this data we trained 362 ANN model architectures in R and were able to predict mitochondrial cardiolipin remodelling based on fatty acyl pools in phospholipids. Our analysis revealed key players in mammalian cardiolipin remodelling: high oleic acid increased lipid diversity, while linoleic acid favoured uniformity. Additionally, to reliably discriminate between plasmanyl/plasmenyl lipids in mouse tissues we conducted lipidomics experiments with ion mobility spectrometry (IMS). All data integration and analysis steps were performed in R. Statistical analysis in R confirmed the validity of this IMS approach for lipid subclass separation, which is especially powerful when combined with accurate retention time characteristics.
Speakers
avatar for Jakob Koch

Jakob Koch

MSc., Medical University of Innsbruck, Biochemical Genetics Laboratory
JK did his BSc and MSc in Chemistry at the LFU Innsbruck. Since beginning of 2019 he is a PhD student in the Biochemical Genetics Laboratory headed by Dr. MA Keller at the Institute of Human Genetics at the Medical University of Innsbruck.In his PhD he's focusses on both, the implementation... Read More →

Tuesday July 9, 2024 12:00 - 12:20 CEST
Attersee
  Biostatistics + epidemiology + bioinformatics
Feedback form isn't open yet.